The 29-year-old, Leicester’s top-scorer last season, was shown a straight red card in the 28th minute by referee Craig Pawson for a two-footed tackle on Mame Diouf.
“Jamie Vardy will serve a three-match suspension with immediate effect after his wrongful dismissal claim was rejected, following an Independent Regulatory Commission hearing,” the FA said.
The Premier League champions had earlier on Tuesday said they were appealing for wrongful dismissal.
“He wants to challenge and get the ball, not make a foul. He touched the ball. Maybe it was yellow,” Leicester manager Claudio Ranieri was quoted as saying by the BBC.
Leicester, 15th in the table, host Everton on 26 December and West Ham United on 31 December, before visiting Middlesbrough on 2 January, with Vardy missing all three matches.
