INTERNATIONAL NEWS - "The rumours are true!" she wrote Twitter. "I will have my own residency at MGM's Park Theater. Get ready for a brand new show!
"It's been my lifelong dream to be a Las Vegas girl, I'm so overjoyed!"
The initial run will include 74 dates, with the possibility of more. According to Variety, Gaga is making more than $1 million (£750,000) per show.
In a statement, the Bad Romance star promised: "I'll leave my heart on the stage every single night."
The 31-year-old has spent much of 2017 touring the US in support of her latest album, Joanne, and is due to play in the UK early next year, having previously postponed dates to deal with "severe physical pain" arising from the medical condition fibromyalgia.
A chronic, long-term illness, its symptoms include extreme tiredness, muscle aches, difficulty sleeping and concentrating.
Explaining the decision to postpone her European tour, Gaga said "trauma and chronic pain" were "keeping me from living a normal life".
"They are also keeping me from what I love the most in the world: performing for my fans.