They are the only changes in the starting line-up for the crucial Test at Nelson Mandela Bay Stadium, while there are three changes on the bench.
Number 8 Whiteley replaces the experienced Duane Vermeulen, who has left the Springbok camp after suffering an elbow injury, while Combrinck, man of the match in last week’s win over the Irish, gets the starting nod over Lwazi Mvovo, who now moves to the bench.
Adriaan Strauss will make his third appearance as the captain as he seeks an inaugural series win for himself and coach Allister Coetzee. The series is currently deadlocked at 1-1 after Ireland’s opening win at Newlands and the Springboks’ victory last week at Emirates Airline Park.